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酮洛芬镇痛作用的研究

论文编号:ZY005    论文字数:8224,页数:17

摘 要:本试验为酮洛芬镇痛作用的研究。采用小鼠迟发性超敏反应试验使用试剂致敏后进行研究;小鼠扭体试验,给药后腹腔注射0.6%醋酸,记录扭体潜伏期及15min内小鼠的扭体次数;免疫试验,小鼠给药第6天,除正常组外其余各组用60mg/kg环磷酰胺腹腔注射造模,造模后第2天,腹腔注射20%羊红细胞0.2ml/只免疫动物,免疫5天后进行试验。酮洛芬可显著提高小鼠痛阈值,延长扭体潜伏期。酮洛芬镇痛效果是显而易见的。

 关键词:酮洛芬;迟发性超敏反应;小鼠扭体试验;免疫试验;镇痛作用


Abstract: This study was undertaken to examine the analgesic effect of ketoprofen. Mice delayed-type hypersensitivity test, using reagents sensitized after administration; mouse writhing test, after administration by intraperitoneal injection of 0.6% acetic acid, records writhing and 15min incubation period with the number of writhing in mice ; immune tests, mice the first six days, in addition to the normal group, the remaining group by intraperitoneal injection of cyclophosphamide 60mg/kg model, modeling the first two days, by intraperitoneal injection of 20% sheep red blood cell 0.2ml / only immune animals , 5 days after immunization to experiment. As the results Ketoprofen can significantly increase the pain threshold in mice and prolong the incubation period writhing. The analgesic effect of ketoprofen is obvious.

 Keywords:Ketoprofen; Delayed type Hypersensitivity; Turning the body to determine the threshould of pain; Immunization;analgesia action

目  录
中文摘要 I
英文摘要 II
目录 III
1. 绪论 1
 1.1  解热镇痛药 1
 1.2 酮洛芬的性状 3
 1.2.1 酮洛芬的药理及应用 3
1.3 酮洛芬的常见剂型 4
1.4 右旋酮洛芬的常见剂型 5
2. 实验部分 7
 2.1 迟发性超敏反应试验 7
 2.2 小鼠扭体试验 8
 2.3 免疫试验 9
3. 结果与讨论 10
 3.1 迟发性超敏反应试验 10
 3.2 小鼠扭体试验 11
 3.3 免疫试验 11
4.总结与展望 13
致谢 15
参考文献 16

酮洛芬镇痛作用的研究......